Generation and Analysis of Large-Scale Data-Driven Mycobacterium tuberculosis Functional Networks for Drug Target Identification

Table 4

Repartition per class of potential drug target proteins, considering those which are central and those considered to be more influential.

	Functional class	Proteins	Drug targets	Central targets	Influential targets
1	Virulence, detoxification, adaptation	176	31	2	1
2	Lipid metabolism	230	75	35	28
3	Information pathways	245	85	21	—
4	Cell wall and cell processes	618	112	52	5
5	Insertion seqs and phages	82	10	—	—
6	PE/PPE	147	69	2	—
7	Intermediary metabolism and respiration	884	262	93	70
8	Unknown	1637	169	24	10
9	Regulatory proteins	176	68	12	—
	Total	4195	881	241	114