Prediction of Enzyme Mutant Activity Using Computational Mutagenesis and Incremental Transduction
Figure 2
(a) An example of a C-alpha trace of a protein with the mutated position indicated (left); the potential profile for the mutated (right, top) and wild-type protein (right, middle) and the residual profile (right, bottom, figure adapted from Masso [18]). (b) Graphical representation of an input vector (residual profile) resulting from the mutation of the T4 lysozyme protein at position 107. Note the sparse nature of the vector; there are lots of positions with zero values and very few non-zero values.
