Research Article

Application of an Integrative Computational Framework in Trancriptomic Data of Atherosclerotic Mice Suggests Numerous Molecular Players

Table 1

GO-analysis. The list of 852 significantly altered genes was submitted to GO analysis elucidating over-represented GO terms. GOT P value represents the hypergeometric test P value score for each GO term. Enrichment represents the ratio of the number of times a GO term occurs in the 852 gene list to the number of times this GO term exists in the list of the Affymetrix 430 2.0 array.

GO annotationGOT P valueEnrichment

Ion transport0.0000000000333/498
Signal transduction0.0000000000444/803
Cell differentiation0.0000000000536/480
Immune response0.0000000000532/250
Metabolic process0.0000000000738/542
Cell adhesion0.0000000001136/387
Protein amino acid phosphorylation0.0000000005932/497
Multicellular organismal development0.0000000012841/770
Proteolysis0.0000000069025/358
Apoptosis0.0000001081424/383
Lipid metabolic process0.0000032881315/212
Protein transport0.0000335238322/465
G-protein coupled receptor signaling 0.0002868129719/436
Oxidation reduction0.0003411998721/510
Cell cycle0.0004368408718/417
Cell division0.0005019499812/231