MRE-mediated miRNA-miRNA interactions network using PredNet. 3753 miRNA-miRNA interactions among 345 miRNA was constructed using PredNet. A list of 16 miRNAs that are highly connected. miRNA-1, miR-133a, miR-133b, miR-221, miR-145, and miRNA-205 are hub miRNAs that are linked to more than 50% of the miRNAs. Cytoscape was used for network visualization. It is worth pointing out the difference between Figures 2 and 3 is that Figure 2 uses ExpNet miRNA-target interactions and Figure 3 uses PredNet miRNA-target interactions.