167915.fig.006
Figure 6: Effect of on DEG detection power. Difference between area under the curve (AUC) of receiver operating characteristic (ROC) curves computed in corrected data and AUC computed in original data, as a function of the value used for , separately for low-, medium, and high-concentration spike-in genes. pyn improves low- and medium-concentration DEG detection power with , with optimal performance at , and has virtually no effect on high-concentration DEG detection power above .