Alternate Phosphorylation/O-GlcNAc Modification on Human Insulin IRSs: A Road towards Impaired Insulin Signaling in Alzheimer and Diabetes

Figure 3

Homology models of human IRS-1 and IRS-2 retrieved through I-TASSER. Five models were predicted as possible 3D structures for both IRS-1 and IRS-2 proteins. The best model for each protein was selected on the basis of Ramachandran plots and their geometrical configuration. (a) Human IRS-1 full-length predicted 3D structures by I-TASSER with Ramachandran plots and geometry. (b) Human IRS-2 predicted 3D structures by I-TASSER with Ramachandran plots and geometry.

(a)

(b)