Prediction of Epitope-Based Peptides for the Utility of Vaccine Development from Fusion and Glycoprotein of Nipah Virus Using In Silico Approach

Figure 4

Docking to predict the binding of predicted and control epitopes to MHC class I molecule, HLA-C∗07:02 and H-2Kb. Binding of “EWISIVPNF” to the binding grooves (a) of the predicted structure of HLA-C∗07:02 (binding energy: −6.9 Kcal/mol) and (b) of the 3D structure of H-2Kb (binding energy: −7.7 Kcal/mol); (c) binding of control peptide (PKB1, KVITFIDL) to the predicted 3D structure of HLA-C∗07:02 (−6.7 Kcal/mol) and (d) H-2Kb (−7.3 Kcal/mol).

(a)

(b)

(c)

(d)