Advances in Bioinformatics

Research Article

Prediction of Epitope-Based Peptides for the Utility of Vaccine Development from Fusion and Glycoprotein of Nipah Virus Using In Silico Approach

Table 2

Most probable predicted epitopes interacting with different MHC class I alleles.

(a)


Epitopes from fusion protein	Interacting MHC Class I alleles	Position	VaxiJen score

EGIAIGPPV	HLA C1203, HLA C0303, HLA A6802, HLA C1402, HLA A*0206	441–449	0.6844

EWISIVPNF	HLA C0303, HLA C1203, HLA C1402, HLA A2301, HLA C*0702	307–315	0.72

FILVRNTLI	HLA C0303, HLA C1203, HLA C0701, HLA A0206, HLA A0201, HLA C0602	315–323	0.72

IIVRVYFPI	HLA C1203, HLA C0303, HLA A0206, HLA A6802, HLA A*0201	276–284	0.72

ISIVPNFIL	HLA C0303, HLA B1502, HLA C1203, HLA B5801, HLA C*1502	309–317	0.72

LLDTVNPSL	HLA C0501, HLA C1203, HLA A0201, HLA C1402, HLA B1502, HLA A0206	480–488	0.7251

TVNPSLISM	HLA C1203, HLA C0501, HLA C0303, HLA B3501, HLA C0702, HLA C1402, HLA B1502, HLA C0701	483–491	0.7251

VGILHYEKL	HLA C0303, HLA C1203, HLA B1502, HLA C0702, HLA C*1402	25–33	0.67

VYFPILTEI	HLA C1402, HLA C1203, HLA A2301, HLA C0303, HLA C0602, HLA C0702, HLA C*0701	280–288	0.72

AQITAGVAL	HLA C0303, HLA B3901, HLA A0206, HLA B1501, HLA B1502, HLA C1203, HLA B*4001	126–134	0.813

EGIAIGPPV	HLA C1203, HLA C0303, HLA A6802, HLA C1402, HLA A*0206	441–449	0.6844

IGFCLITKR	HLA C0303, HLA C1203, HLA A3101, HLA A6801, HLA C*1402	328–336	2.4587

ISFIIVEKK	HLA C1203, HLA A6801, HLA A1101, HLA C1502, HLA C0303, HLA C1402	513–521	2.2805

ISMLSMIIL	HLA B1502, HLA C1203, HLA C1402, HLA C0303, HLA C*1502	489–497	0.5006

ITFISFIIV	HLA C1203, HLA A6802, HLA A0206, HLA C1402, HLA A*3001	510–518	0.914

LSLDLALSK	HLA C1502, HLA A3001, HLA A1101, HLA C1203, HLA C0303, HLA C1402	197–205	0.9847

ILTEIQQAY	HLA C1502, HLA C1203, HLA A1101, HLA C0303, HLA C1402, HLA A3001	284–292	0.721

MLSMIILYV	HLA-A02:01, HLA-A02:06, HLA-A68:02, HLA- C12:03, HLA-C*14:02	491–499	0.6397

NTYSRLEDR	HLA A6801, HLA C0303, HLA C1203, HLA C1402, HLA C0701, HLA C1502, HLA A*3101	523–531	1.5575

PTSSGDLYY	HLA A2902, HLA C1203, HLA C0303, HLA A0101, HLA B1502, HLA C1402, HLA C*0501	535–543	0.5252

TAAQITAGV	HLA A6802, HLA C1203, HLA C0303, HLA C0501, HLA C*1502	124–132	0.7373

TELSLDLAL	HLA C0303, HLA B1502, HLA B4001, HLA B4002, HLA C1203, HLA B3901, HLA C*0702	195–203	0.9593

VRPTSSGDL	HLA B1502, HLA C0602, HLA C1402, HLA C1203, HLA C0701, HLA C0702	533–541	1.0043

YEKLSKIGL	HLA B1502, HLA C1203, HLA C0303, HLA B4001, HLA B*4002	30–38	0.67

YIKEAQRLL	HLA C1203, HLA B1502, HLA C0701, HLA C0602, HLA C0303, HLA C0702	473–481	0.7251

YYIIVRVYF	HLA A2301, HLA C1402, HLA A2402, HLA C0702, HLA C1203, HLA C0303, HLA B*1502	274–282	0.72

(b)


Epitopes from glycoprotein	Interacting MHC Class I alleles	Position	VaxiJen score

FIEISDQRL	HLA B1502, HLA C0303, HLA C1203, HLA C0501, HLA C0702, HLA C1502	428	1.5463

FPAVGFLVR	HLA C0303, HLA C1203, HLA A6801, HLA B1502, HLA B*3501	364–372	1.053

ISCPNPLPF	HLA C0303, HLA B5801, HLA C1203, HLA B1501, HLA B1502, HLA C1402, HLA C1502, HLA B3501	164–172	0.921

ITIPANIGL	HLA C0303, HLA C1203, HLA A6802, HLA B1502, HLA A0206, HLA C1502, HLA C*1402	118–126	1.2697

TEIGPKVSL	HLA C0303, HLA B4001, HLA C1203, HLA B1502, HLA B4002, HLA B3901	103–111	1.337

TLYFPAVGF	HLA C0303, HLA C1402, HLA B1502, HLA C1203, HLA A*3201	361–369	0.9600

VFYQASFSW	HLA C1203, HLA C1402, HLA C0303, HLA B5801, HLA A*2301	452–460	1.2161

VGFLVRTEF	HLA C1203, HLA C0702, HLA C1402, HLA B1502, HLA C*0303	367–375	1.443

YFPAVGFLV	HLA C1203, HLA A0206, HLA C1402, HLA A6802, HLA A*0201	363–371	0.834

MPYGPSGIK	HLA C0303, HLA C1203, HLA B1502, HLA A0301, HLA C1402, HLA A1101	349–357	1.243

RLSIGSPSK	HLA C0303, HLA C1203, HLA A0301, HLA A3001, HLA C1402, HLA A1101	435–443	1.134

SLIDTSSTI	HLA C0303, HLA C1203, HLA A0201, HLA B1502, HLA C1402, HLA A0206, HLA A3201, HLA B1501	110–118	0.509