Prediction of Epitope-Based Peptides for the Utility of Vaccine Development from Fusion and Glycoprotein of Nipah Virus Using In Silico Approach

Table 3

Most probable predicted epitopes interacting with different MHC class II alleles.

(a)

Epitopes from fusion protein	Interacting class II MHC alleles	Antigenic scores
FILVRNTLISNIEIG	HLA DRB1*0701, HLA DRB1*0101, HLA DRB1*0405, HLA DRB5*0101, HLA; DRB1*0404, HLA DRB1*1101, HLA DRB1*1302, HLA DRB1*0401	1.109	315
EIGFCLITKRSVICN	HLA-DRB1*11:01 HLA-DRB1*07:01 HLA-DRB1*01:01 HLA-DRB1*04 HLA-; DRB1*09:01	1.4646	327
IEIGFCLITKRSVIC	HLA-DRB1*11:01 HLA-DRB1*07:01 HLA-DRB1*01:01 HLA-DRB1*04 HLA-; DRB1*09:01	1.7736	326
NIEIGFCLITKRSVI	HLA-DRB1*11:01 HLA-DRB1*07:01 HLA-DRB1*01:01 HLA-DRB1*04 HLA-; DRB1*09:01	1.5682	325
SNIEIGFCLITKRSV	HLA-DRB1*11:01 HLA-DRB1*07:01 HLA-DRB1*01:01 HLA-DRB1*04 HLA-; DRB1*09:01	1.8516	324
SVGILHYEKLSKIGL	HLA-DRB1*11:01 HLA-DRB1*01:01 HLA-DRB4*01:01 HLA-DRB1*04 HLA-; DPA1*03:01/DPB1*04:02	1.3695	24
VGILHYEKLSKIGLV	HLA-DRB1*11:01 HLA-DRB1*01:01 HLA-DRB4*01:01 HLA-DPA1*03:01/DPB1*04:02; HLA-DRB5*01:01	1.2192	25
DNSEWISIVPNFILV	HLA DRB1*0701, HLA DRB1*0101, HLA DRB5*0101, HLA DRB1*0405, HLA; DRB1*1501, HLA DRB1*1302, HLA DRB1*0404, HLA DRB1*09, HLA; DPA1*0201/DPB1*0101	0.938	304
EWISIVPNFILVRNT	HLA DRB1*0701, HLA DRB1*1501, HLA DRB1*0101, HLA DRB5*0101, HLA; DRB1*0404, HLA DRB1*0405, HLA DRB1*1302, HLA DPA1*0201/DPB1*0101	0.781	307
IISLGKYLGSVNYNS	HLA DRB1*0401, HLA DRB1*0101, HLA DRB1*0405, HLA DRB1*0404, HLA; DQA1*0501/DQB1*0301, HLA DRB1*1101	0.633	426
NDNSEWISIVPNFIL	HLA DRB1*0701, HLA DRB1*0101, HLA DRB5*0101, HLA DRB1*0405, HLA; DRB1*1501, HLA DRB1*1302, HLA DRB1*0404, HLA DRB1*09	0.58	303
NFILVRNTLISNIEI	HLA DRB1*0701, HLA DRB1*0101, HLA DRB1*0405, HLA DRB5*0101, HLA; DRB1*0404, HLA DRB1*1101, HLA DRB1*1302, HLA DRB1*0401, HLA DRB1*1501	0.74	314
PNFILVRNTLISNIE	HLA DRB1*0701, HLA DRB1*0101, HLA DRB1*0405, HLA DRB5*0101, HLA; DRB1*0404, HLA DRB1*1101, HLA DRB1*1302, HLA DRB1*0401, HLA DRB1*1501,; HLA DRB4*0101	0.612	313
SEWISIVPNFILVRN	HLA DRB1*0701, HLA DRB1*0101, HLA DRB5*0101, HLA DRB1*1501, HLA; DRB1*0405, HLA DRB1*1302, HLA DRB1*0404, HLA DRB1*09, HLA; DPA1*0201/DPB1*0101	0.728	306
WISIVPNFILVRNTL	HLA DRB1*0701, HLA DRB1*0101, HLA DRB5*0101, HLA DRB1*1501, HLA; DRB1*0405, HLA DRB1*0404, HLA DRB1*1302, HLA DPA1*0201/DPB1*0101	0.681	308
GILHYEKLSKIGLVK	HLA-DRB1*11:01 HLA-DRB1*01:01 HLA-DRB4*01:01 HLA-DPA1*03:01/DPB1*04:02; HLA-DRB1*09:01	0.6020	26

(b)

Epitopes from glycoprotein	Interacting MHC class II alleles	VaxiJen scores	Position
ANIGLLGSKISQSTA	HLA DRB1*0101, HLA DQA1*0501/DQB1*0301, HLA DRB1*0404, HLA DRB1*1501,; HLA DRB1*1101	1.1268	122–136
DTLYFPAVGFLVRTE	HLA DRB1*0101, HLA DPA1*0201/DPB1*0101, HLA DPA1*0103/DPB1*0201, HLA; DPA1*01/DPB1*0401, HLA-DPA1*0301/DPB1*0402, HLA DRB1*0701, HLA; DQA1*0501/DQB1*0301	0.9628	360–374
GDTLYFPAVGFLVRT	HLA DRB1*0101, HLA DPA1*0201/DPB1*0101, HLA DPA1*0103/DPB1*0201, HLA; DPA1*01/DPB1*0401, HLA DPA1*0301/DPB1*0402, HLA DRB1*0701, HLA; DQA1*0501/DQB1*0301	0.6663	359–373
GPKVSLIDTSSTITI	HLA DRB1*0701, HLA DRB1*1302, HLA DRB1*0101, HLA DRB1*0404, HLA; DRB1*0401	0.8609	106–120
IPANIGLLGSKISQS	HLA DRB1*0101, HLA DQA1*0501/DQB1*0301, HLA DRB1*0404, HLA DRB1*1501,; HLA DRB1*1101	1.4106	120–134
ITIPANIGLLGSKIS	HLA DRB1*0101, HLA DRB1*0404, HLA DRB1*1501, HLA DRB1*1101, HLA; DQA1*0501/DQB1*0301	1.2611	118–132
PANIGLLGSKISQST	HLA DRB1*0101, HLA DQA1*0501/DQB1*0301, HLA DRB1*0404, HLA DRB1*1501,; HLA DRB1*1101	1.1782	121–135
TLYFPAVGFLVRTEF	HLA DRB1*0101, HLA DPA1*0201/DPB1*0101, HLA DPA1*01/DPB1*0401, HLA; DPA1*0103/DPB1*0201, HLA DPA1*0301/DPB1*0402, HLA DRB1*0701, HLA; DQA1*0501/DQB1*0301	1.1201	361–375
VFYQASFSWDTMIKF	HLA DRB3*0101, HLA DRB1*0701, HLA DPA1*0103/DPB1*0201, HLA; DPA1*0201/DPB1*0101, HLA DRB1*0101	0.507	452–466