In Silico Investigation of Flavonoids as Potential Trypanosomal Nucleoside Hydrolase Inhibitors

Figure 8

(a) Docked position of (i) apigenin (stick figure) in the binding pocket of IAG-NH and (ii) quercetin (stick figure) in the binding pocket of IG-NH. (b) LigPlot figures of (i) apigenin docked in IAG-NH and (ii) quercetin docked in IG-NH. Amino acid residues forming hydrophobic interactions were highlighted in red circles. Amino acids contributing to hydrogen bonds were labelled green and hydrogen bonds were indicated as dotted lines with bond length labelled in green.

(a)

(b)