In Silico Analysis of Gene Expression Network Components Underlying Pigmentation Phenotypes in the Python Identified Evolutionarily Conserved Clusters of Transcription Factor Binding Sites

Figure 3

Heat map of orthologous coat color genes illustrating pairwise percent identity. Twenty-three orthologous genes modulating pigmentation and coat color in mammals are shown as a heat map illustrating pairwise protein sequence percent identity based on BLASP best hit between the listed species. The highest percent identity is shown in red, moderate percent identity is shown in magenta, and the lowest percent identity is shown in blue. The pleiotropic effects associated with each gene are included within the parentheses immediately following each gene name. Note: gray boxes (RAB38 and SLC24A5) under pyth2Tham_sirt indicate missing sequences; in this case, the garter snake orthologs of these two genes were not available in the NCBI database. pyth2hum: python and human; pyth2mouse: python and mouse; pyth2dog: python and dog; pyth2horse: python and horse; pyth2cow: python and cow; pyth2chick: python and chicken; pyth2anole: python and anole lizard; pyth2Tham_sirt: python and garter snake.