In Silico Analysis of Gene Expression Network Components Underlying Pigmentation Phenotypes in the Python Identified Evolutionarily Conserved Clusters of Transcription Factor Binding Sites

Figure 7

Orthologous multiple sequence alignment of CREB across species. CREB sequences exhibit considerable conservation throughout much of the alignment with a few notable point differences with the conserved regions. The basic-leucine zipper DNA binding domain occurs in the C-terminal region (284 to 342 in the python sequence). Within the DNA recognition strong conservation is observed among the species and only king cobra exhibits considerable divergent sequence identity in this region.