Research Article
Bioinformatics Approach for Prediction of Functional Coding/Noncoding Simple Polymorphisms (SNPs/Indels) in Human BRAF Gene
Table 3
Functional SNPs predicted by triple servers.
| | Protein ID | Amino acid change | SIFT prediction | Score | PolyPhen-2 prediction | Score | SNAP2 | Score |
| | ENSP00000288602 | Q93H | Damaging | 0 | Probably damaging | 0.974 | Effect | 15 | | ENSP00000288602 | A246P | Damaging | 0 | Probably damaging | 0.999 | Effect | 73 | | ENSP00000288602 | T241M | Damaging | 0 | Probably damaging | 1 | Effect | 72 | | ENSP00000288602 | T241R | Damaging | 0 | Probably damaging | 1 | Effect | 73 | | ENSP00000288602 | T241P | Damaging | 0 | Probably damaging | 1 | Effect | 86 | | ENSP00000288602 | L245F | Damaging | 0 | Probably damaging | 0.999 | Effect | 64 | | ENSP00000288602 | F247S | Damaging | 0.01 | Possibly damaging | 0.443 | Effect | 77 | | ENSP00000288602 | F247L | Damaging | 0 | Probably damaging | 0.987 | Effect | 70 | | ENSP00000288602 | P367L | Damaging | 0.01 | Probably damaging | 0.999 | Effect | 36 | | ENSP00000288602 | P402H | Damaging | 0 | Probably damaging | 0.948 | Effect | 29 | | ENSP00000288602 | G464A | Damaging | 0 | Probably damaging | 0.999 | Effect | 50 | | ENSP00000288602 | G464V | Damaging | 0 | Probably damaging | 1 | Effect | 70 | | ENSP00000288602 | G464E | Damaging | 0 | Probably damaging | 1 | Effect | 84 | | ENSP00000288602 | G466R | Damaging | 0 | Probably damaging | 0.996 | Effect | 95 | | ENSP00000288602 | G469R | Damaging | 0 | Probably damaging | 1 | Effect | 90 | | ENSP00000288602 | V471F | Damaging | 0 | Probably damaging | 0.954 | Effect | 78 | | ENSP00000288602 | V471I | Damaging | 0 | Possibly damaging | 0.22 | Effect | 37 | | ENSP00000288602 | I463S | Damaging | 0 | Possibly damaging | 0.714 | Effect | 75 | | ENSP00000288602 | F468S | Damaging | 0 | Possibly damaging | 0.67 | Effect | 82 | | ENSP00000288602 | G464R | Damaging | 0 | Probably damaging | 1 | Effect | 79 | | ENSP00000288602 | R444W | Damaging | 0 | Probably damaging | 0.999 | Effect | 67 | | ENSP00000288602 | G466A | Damaging | 0 | Probably damaging | 0.97 | Effect | 87 | | ENSP00000288602 | G466V | Damaging | 0 | Probably damaging | 0.983 | Effect | 93 | | ENSP00000288602 | G466E | Damaging | 0 | Probably damaging | 0.996 | Effect | 94 | | ENSP00000288602 | G469A | Damaging | 0 | Probably damaging | 0.969 | Effect | 73 | | ENSP00000288602 | G469V | Damaging | 0 | Probably damaging | 1 | Effect | 89 | | ENSP00000288602 | G469E | Damaging | 0 | Probably damaging | 1 | Effect | 93 | | ENSP00000288602 | L485F | Damaging | 0 | Probably damaging | 0.999 | Effect | 5 | | ENSP00000288602 | E501K | Damaging | 0.01 | Probably damaging | 0.997 | Effect | 84 | | ENSP00000288602 | E501G | Damaging | 0 | Probably damaging | 1 | Effect | 81 | | ENSP00000288602 | K483Q | Damaging | 0 | Probably damaging | 0.999 | Effect | 79 | | ENSP00000288602 | L485S | Damaging | 0 | Probably damaging | 0.999 | Effect | 42 | | ENSP00000288602 | K499N | Damaging | 0 | Probably damaging | 0.884 | Effect | 58 | | ENSP00000288602 | L505F | Damaging | 0.01 | Possibly damaging | 0.698 | Effect | 41 | | ENSP00000288602 | P490S | Damaging | 0 | Possibly damaging | 0.494 | Effect | 31 | | ENSP00000288602 | G534R | Damaging | 0 | Probably damaging | 1 | Effect | 34 | | ENSP00000288602 | C532Y | Damaging | 0 | Probably damaging | 1 | Effect | 75 | | ENSP00000288602 | N581H | Damaging | 0 | Probably damaging | 1 | Effect | 73 | | ENSP00000288602 | N581D | Damaging | 0.05 | Possibly damaging | 0.503 | Effect | 76 | | ENSP00000288602 | H574Q | Damaging | 0 | Probably damaging | 0.999 | Effect | 89 | | ENSP00000288602 | F595L | Damaging | 0 | Probably damaging | 1 | Effect | 92 | | ENSP00000288602 | G596R | Damaging | 0 | Probably damaging | 1 | Effect | 95 | | ENSP00000288602 | K601E | Damaging | 0 | Probably damaging | 0.997 | Effect | 58 | | ENSP00000288602 | L597Q | Damaging | 0 | Probably damaging | 1 | Effect | 71 | | ENSP00000288602 | L597R | Damaging | 0 | Probably damaging | 0.999 | Effect | 81 | | ENSP00000288602 | N581S | Damaging | 0.04 | Possibly damaging | 0.517 | Effect | 56 | | ENSP00000288602 | T599I | Damaging | 0 | Probably damaging | 0.997 | Effect | 62 | | ENSP00000288602 | G596V | Damaging | 0 | Probably damaging | 1 | Effect | 92 | | ENSP00000288602 | K601I | Damaging | 0 | Probably damaging | 0.986 | Effect | 18 | | ENSP00000288602 | F595S | Damaging | 0 | Probably damaging | 1 | Effect | 95 | | ENSP00000288602 | D594E | Damaging | 0 | Probably damaging | 0.999 | Effect | 90 | | ENSP00000288602 | I592M | Damaging | 0 | Probably damaging | 0.997 | Effect | 55 | | ENSP00000288602 | K601N | Damaging | 0 | Probably damaging | 0.939 | Effect | 49 | | ENSP00000288602 | R603Q | Damaging | 0.03 | Probably damaging | 0.971 | Effect | 37 | | ENSP00000288602 | D638E | Damaging | 0 | Probably damaging | 1 | Effect | 91 | | ENSP00000420119 | Q78H | Damaging | 0 | Probably damaging | 0.948 | Effect | 41 | | ENSP00000288602 | R671Q | Damaging | 0 | Probably damaging | 0.996 | Effect | 28 | | ENSP00000288602 | Q709R | Damaging | 0.01 | Possibly damaging | 0.776 | Effect | 45 | | ENSP00000288602 | L692S | Damaging | 0 | Probably damaging | 0.999 | Effect | 30 | | ENSP00000288602 | R719C | Damaging | 0 | Probably damaging | 0.996 | Effect | 34 | | ENSP00000288602 | A749D | Damaging | 0.03 | Possibly damaging | 0.819 | Effect | 47 | | ENSP00000288602 | R719L | Damaging | 0 | Possibly damaging | 0.551 | Effect | 45 | | ENSP00000418033 | N9H | Damaging | 0 | Probably damaging | 0.98 | Effect | 66 | | ENSP00000418033 | F23L | Damaging | 0 | Probably damaging | 0.993 | Effect | 69 | | ENSP00000418033 | G24R | Damaging | 0 | Probably damaging | 1 | Effect | 90 | | ENSP00000418033 | K29E | Damaging | 0.04 | Probably damaging | 0.909 | Effect | 41 | | ENSP00000418033 | L25Q | Damaging | 0 | Probably damaging | 0.996 | Effect | 42 | | ENSP00000418033 | L25R | Damaging | 0 | Probably damaging | 0.996 | Effect | 61 | | ENSP00000418033 | T27I | Damaging | 0.01 | Probably damaging | 0.996 | Effect | 64 | | ENSP00000418033 | G24Y | Damaging | 0 | Probably damaging | 1 | Effect | 79 | | ENSP00000418033 | K29I | Damaging | 0 | Probably damaging | 0.907 | Effect | 8 | | ENSP00000418033 | F23S | Damaging | 0 | Probably damaging | 0.996 | Effect | 87 | | ENSP00000418033 | D22E | Damaging | 0 | Probably damaging | 0.997 | Effect | 80 | | ENSP00000418033 | I20M | Damaging | 0 | Probably damaging | 0.945 | Effect | 28 | | ENSP00000418033 | K29N | Damaging | 0 | Probably damaging | 0.949 | Effect | 35 | | ENSP00000418033 | D66E | Damaging | 0 | Probably damaging | 0.997 | Effect | 93 | | ENSP00000419060 | P10H | Damaging | 0 | Probably damaging | 0.976 | Effect | 6 | | ENSP00000419060 | G77R | Damaging | 0 | Probably damaging | 0.962 | Effect | 89 | | ENSP00000419060 | I71S | Damaging | 0 | Probably damaging | 0.999 | Effect | 86 | | ENSP00000419060 | F76S | Damaging | 0 | Probably damaging | 0.999 | Effect | 64 | | ENSP00000419060 | R52W | Damaging | 0 | Probably damaging | 0.976 | Effect | 55 | | ENSP00000419060 | G74V | Damaging | 0 | Possibly damaging | 0.351 | Effect | 81 | | ENSP00000419060 | G74E | Damaging | 0 | Possibly damaging | 0.51 | Effect | 87 | | ENSP00000419060 | G77A | Damaging | 0 | Possibly damaging | 0.344 | Effect | 52 | | ENSP00000419060 | G77V | Damaging | 0 | Possibly damaging | 0.276 | Effect | 82 | | ENSP00000419060 | G77E | Damaging | 0 | Probably damaging | 0.883 | Effect | 89 | | ENSP00000419060 | L93F | Damaging | 0 | Probably damaging | 0.919 | Effect | 6 | | ENSP00000419060 | K107E | Damaging | 0 | Probably damaging | 0.989 | Effect | 50 | | ENSP00000419060 | E109K | Damaging | 0.01 | Probably damaging | 0.992 | Effect | 91 | | ENSP00000419060 | E109G | Damaging | 0 | Probably damaging | 0.998 | Effect | 90 | | ENSP00000419060 | C140Y | Damaging | 0 | Probably damaging | 0.932 | Effect | 81 | | ENSP00000419060 | N189H | Damaging | 0 | Probably damaging | 0.996 | Effect | 66 | | ENSP00000419060 | N189D | Damaging | 0.03 | Probably damaging | 0.998 | Effect | 66 | | ENSP00000419060 | H182Q | Damaging | 0 | Probably damaging | 0.999 | Effect | 72 | | ENSP00000419060 | F203L | Damaging | 0 | Probably damaging | 1 | Effect | 89 | | ENSP00000419060 | G204R | Damaging | 0 | Probably damaging | 0.999 | Effect | 90 | | ENSP00000419060 | K209E | Damaging | 0 | Possibly damaging | 0.477 | Effect | 51 | | ENSP00000419060 | L205Q | Damaging | 0 | Probably damaging | 1 | Effect | 56 | | ENSP00000419060 | L205R | Damaging | 0 | Probably damaging | 1 | Effect | 75 | | ENSP00000419060 | N189S | Damaging | 0.03 | Probably damaging | 0.989 | Effect | 43 | | ENSP00000419060 | G204V | Damaging | 0 | Possibly damaging | 0.242 | Effect | 87 | | ENSP00000419060 | F203S | Damaging | 0 | Probably damaging | 1 | Effect | 94 | | ENSP00000419060 | D202E | Damaging | 0 | Probably damaging | 1 | Effect | 87 | | ENSP00000419060 | I200M | Damaging | 0 | Probably damaging | 1 | Effect | 32 | | ENSP00000419060 | R211Q | Damaging | 0.05 | Probably damaging | 0.979 | Effect | 8 | | ENSP00000419060 | D246E | Damaging | 0 | Probably damaging | 0.998 | Effect | 96 | | ENSP00000419060 | R279Q | Damaging | 0.02 | Probably damaging | 1 | Effect | 56 | | ENSP00000419060 | Q317R | Damaging | 0.03 | Probably damaging | 0.975 | Effect | 2 | | ENSP00000419060 | R327C | Damaging | 0 | Possibly damaging | 0.291 | Effect | 43 | | ENSP00000419060 | A357D | Damaging | 0.03 | Possibly damaging | 0.507 | Effect | 22 | | ENSP00000419060 | K107N | Damaging | 0 | Probably damaging | 0.994 | Effect | 32 |
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