Research Article

In Silico Analysis of SNPs in PARK2 and PINK1 Genes That Potentially Cause Autosomal Recessive Parkinson Disease

Table 3

SNPs within PINK1 gene that affect the structure and function and stability of PINK1 protein predicted by SIFT, PolyPhen, and I-mutant tools, respectively.

SNP IDAA
change
SIFT
result
SIFT
score
PolyPhen
result
PolyPhen
score
StabilityI-mutant score

rs7349186P305LDeleterious0.004Damaging0.99Decreased7