Advances in Chemistry

Research Article

Synthesis, Characterization, and Antihypertensive Evaluation of Some Novel 2,2,8,8-Tetramethyl-2,3,7,8-tetrahydro-4,6-diamino-3,7-dihydroxy-6,7-epoxy-benzo-[1,2-b:5,4-b′]dipyran Derivatives

Physical and spectral analysis of 2,2,8,8-tetramethyl-2,3,7,8-tetrahydro-4,6-diamino-3,7-dihydroxy-benzo[1,2-:5,4-] dipyran 8a–e.


Comp. code	R	Molecular formula		FTIR (cm⁻¹)	¹H NMR (ppm)	Mass (M + 1)

8a		C₃₀H₃₆O₄N₂	2.8	3352.7 (O–H str), 2934.2 (Ali C–H str), 1138.8 (C–N str), 1615 (C=C str)	δ7.16 (m, 12H), δ2.15 (s, 4H), δ1.30 (s, 12H)	489.1

8b		C₂₆H₄₂O₄N₄	2.7	3317.8 (O–H str), 2924.4 (Ali C–H str), 1094.4 (C–N str), 1229.8 (C–O str), 1611.1 (C=C str)	δ5.37 (d, 1H), δ2.15 (s, 6H), δ1.26 (s, 12H)	475.4

8c		C₃₀H₃₂Cl₄O₄N₂	2.3	3395.5 (O–H str), 2927.9 (Ali C–H str), 1256.6 (C–O str), 1655.1 (C=C str), 1094.6 (C–N)	δ7.41 (s, 1H), δ6.37 (s, 1H), δ4.03 (d, 4H), δ1.50 (s, 4H) δ1.43 (s, 12H)	625.0

8d		C₄₀H₄₀O₄N₂	2.7	3266.4 (O–H str), 2940.8 (Ali C–H str), 1251.6 (C–O str), 1650.8 (C=C str), 1029.1 (C–N)	δ7.43 (m, 22H), δ2.29 (s, 6H), δ1.20 (s, 12H)	613.6

8e		C₂₃H₃₇O₄N₂	3.6	3427 (O–H str), 3020.7 (Ali C–H str), 1216.4 (C–O str), 1562.7 (C=C str), 1041.1 (C–N)	δ3.47 (m, 4H), δ2.29 (s, 4H), δ1.20 (s, 12H)	421.1