Aloesin Suppresses Cell Growth and Metastasis in Ovarian Cancer SKOV3 Cells through the Inhibition of the MAPK Signaling Pathway

Figure 4

Aloesin inhibits tumor growth in a xenograft model of ovarian cancer. (a) A xenograft model of ovarian cancer was established using SKOV3 cells. Mice from each group were injected with aloesin (20 mg/kg or 40 mg/kg) daily until 7 weeks. Mice without aloesin injection was fed as control. Tumor volumes in each group were calculated and shown. (b) Seven weeks after inoculation, tumors from each group of mice were dissected. (c) Dissected tumors were weighed. The average weight of tumors from each group of mice was calculated. (d) The expression of PCNA and cleaved caspase-3 was detected in xenografts by IHC. ; .

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