High PINCH1 Expression in Human Laryngeal Carcinoma Associates with Poor Prognosis

Table 5

Multivariate Cox regression analysis for overall and disease-free survival.

	Multivariate analysis
	Overall survival			Disease-free survival
	HR	95% CI	value	HR	95% CI	value
Grade			0.038			0.017
Grade II/grade I	0.734	0.304–1.771	0.492	0.810	0.319–2.057	0.658
Grade III/grade I	3.711	0.863–15.956	0.078	4.386	1.091–17.628	0.037
N; (No/N1–3)	2.169	1.113–4.227	0.023	3.076	1.508–6.274	0.002
PINCH1 cytoplasmic; Low/high	2.268	1.088–4.727	0.029
PINCH1 nuclear; Low/high	0.518	0.135–1.987	0.337	0.590	0.168–2.075	0.411

HR: hazards ratio; CI: confidence interval. Significant values appear in bold. Only parameters that showed a significant difference by univariate analysis were included in the multivariate analysis.