Research Article

MicroRNA-378 Promotes Osteogenesis-Angiogenesis Coupling in BMMSCs for Potential Bone Regeneration

Figure 3

MiR-378 enhanced osteogenesis in vitro. BMMSCs that were transfected with miR-378 mimics, miR-378 inhibitor, or the miR-negative control. (a) MiR-378 expression was enhanced and reduced by transfection of miR-378 mimics and miR-378 inhibitor. (b) Osteogenesis gene (Runx2, BMP2, Ocn, and Col1) was evaluated by qRT-PCR for angiogenesis enhancement at different time points after transfection including 2, 7, and 14 days. (c) ALP and alizarin red staining were enhanced and reduced by overexpression and inhibition of miR-378 expression, respectively. and ; .
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