SGK1 Mediates Hypoxic Pulmonary Hypertension through Promoting Macrophage Infiltration and Activation

<div>SGK1 deficiency alleviated the development of PAH in mice. (a) Graphs of right ventricular hypertrophy index (right ventricle/left ventricle plus septum weight, RV/(LV+S)) from mice exposed to 28 days of normoxia or hypoxia. (b) Graphs of right ventricular mass to body weight ratio (RV/BW) from mice exposed to 28 days of normoxia or hypoxia. (c) Representative images of right ventricular systolic pressure (RVSP) waves (red) from WT and SGK1<sup>-/-</sup> mice exposed to 28 days of normoxia or hypoxia. 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Analytical Cellular Pathology

fig2

Figure 2

Figure 2: SGK1 Mediates Hypoxic Pulmonary Hypertension through Promoting Macrophage Infiltration and Activation 