The Impact of Type II Diabetes on Tongue Dysplasia and p16-Related Aging Process: An Experimental Study

Table 1

Histopathological and immunohistochemical findings of control and DM groups.

	Control	DM
Epithelial hyperplasia (μm)	235.0 (136.2-403.5)	120.4 (60.3-277.6)	0.005
Length of filiform papillae (μm)	221.8 (162.0-642.9)	99.5 (67.2-211.8)	0.001
Width of filiform papillae (μm)	87.2 (61.5-159.6)	55.6 (21.0-80.5)	0.006
Capillary proliferation (0/1/2/3)^#	1/7/0/0	1/9/4/0	0.244
Dysplasia (0/1/2/3)^#	6/2/0/0	6/8/0/0	0.204
MNL infiltration (0/1/2/3)^#	5/3/0/0	8/6/0/0	0.204
p16 (%)	40 (10-70)	90 (15-90)	0.006
p53 (%0/%1/%2)^#	3/4/1	3/7/4	0.588
Ki67 (%0/%1)^#	4/4	5/9	0.662
Bcl-2 (%0/%1/%2)^#	5/3/0	7/6/1	0.686

As the parameters did not show a normal distribution, the data were shown as median (min-max) values. Mann-Whitney test was used for comparisons; ^#Chi-square test was used to compare ratios.