Ginsenoside Rg3 Prolongs Survival of the Orthotopic Hepatocellular Carcinoma Model by Inducing Apoptosis and Inhibiting Angiogenesis

Figure 6

The molecular mechanical illustration. In order to further elucidate the mechanisms of the Rg3 antitumor effects, the orthotopic HCC tumor-bearing mouse was followed up to 3 months with the 30-day oral taking of Rg3 in the early stage of tumor development when the initial tumor was implanted in the liver. Results showed that apoptosis induction and angiogenesis was significantly detected in tumor tissue by Rg3 treatment, contributing to the tumor shrinkage and negative remote metastasis. Rg3 initialized the tumor apoptotic progress, which then weakened the tumor volume and its capability to produce the vascularized network for tumor growth and further metastasis.