Increased COX-2 Immunostaining in Urothelial Carcinoma of the Urinary Bladder Is Associated with Invasiveness and Poor Prognosis

<div>COX-2 immunostaining. (a) A section from a normal urinary bladder mucosa shows low COX-2 immunostaining in the apical portion of umbrella cells (200x). (b) A section from a papillary UCB, (c) a section from an invasive UCB, and (d) a section from high-grade UCB. Cytoplasmic COX-2 immunostaining is higher in invasive and high-grade UCB (100x). Immunohistochemistry was done using an anti-COX-2 antibody, diaminobenzidine as the chromogen, and haematoxylin as a counterstain.</div>

Analytical Cellular Pathology

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Figure 1

Figure 1: Increased COX-2 Immunostaining in Urothelial Carcinoma of the Urinary Bladder Is Associated with Invasiveness and Poor Prognosis 