Identification and Verification of the Main Differentially Expressed Proteins in Gastric Cancer via iTRAQ Combined with Liquid Chromatography-Mass Spectrometry

Table 1

The top 50 proteins with upregulation multiples greater than 1.2-fold.

N	Accession	Description	Up fold	value
1	A0A087X079	Ig gamma-1 chain C region OS=Homo sapiens GN=IGHG1 PE=1 SV=1 (A0A087X079_HUMAN)	4.683184	1.29-25
2	O14604	Thymosin beta-4, Y-chromosomal OS=Homo sapiens GN=TMSB4Y PE=1 SV=3 (TYB4Y_HUMAN)	3.016063	8.25-14
3	P31327	Carbamoyl-phosphate synthase (ammonia), mitochondrial OS=Homo sapiens GN=CPS1 PE=1 SV=2 (CPSM_HUMAN)	2.721231	1.33-11
4	A1A5C5	RRBP1 protein OS=Homo sapiens GN=RRBP1 PE=2 SV=1 (A1A5C5_HUMAN)	2.547532	2.67-10
5	P25815	Protein S100-P OS=Homo sapiens GN=S100P PE=1 SV=2 (S100P_HUMAN)	2.528605	3.71-10
6	P0DMU9	Cancer/testis antigen family 45 member A10 OS=Homo sapiens GN=CT45A10 PE=2 SV=1 (CT45A_HUMAN)	2.486112	7.72-10
	Q86XP6	Gastrokine-2 OS=Homo sapiens GN=GKN2 PE=1 SV=2 (GKN2_HUMAN)	2.283884	2.51-08
8	B3KY79	cDNA FLJ46620 fis, clone TLUNG2000654, highly similar to keratin, type II cytoskeletal 7 OS=Homo sapiens PE=2 SV=1 (B3KY79_HUMAN)	2.215252	8.09-08
9	A8K2T5	cDNA FLJ77047, highly similar to Homo sapiens zinc finger protein 217 (ZNF217), mRNA (fragment) OS=Homo sapiens PE=2 SV=1 (A8K2T5_HUMAN)	2.209209	8.97-08
10	B4E2T6	cDNA FLJ58231, highly similar to NMDA receptor-regulated protein 1 OS=Homo sapiens PE=2 SV=1 (B4E2T6_HUMAN)	2.045548	1.42-06
11	D6CHE9	Proteinase 3 OS=Homo sapiens GN=PRTN3 PE=2 SV=1 (D6CHE9_HUMAN)	2.038724	1.59-06
12	H0YJL6	Ena/VASP-like protein (fragment) OS=Homo sapiens GN=EVL PE=1 SV=1 (H0YJL6_HUMAN)	2.036708	1.64-06
13	Q5T619	Zinc finger protein 648 OS=Homo sapiens GN=ZNF648 PE=2 SV=1 (ZN648_HUMAN)	2.035727	1.67-06
14	Q658S4	Putative uncharacterized protein DKFZp666N164 (fragment) OS=Homo sapiens GN=DKFZp666N164 PE=2 SV=1 (Q658S4_HUMAN)	1.990709	3.53-06
15	B2RBL3	Thymidine phosphorylase OS=Homo sapiens PE=2 SV=1 (B2RBL3_HUMAN)	1.988453	3.66-06
16	P98088	Mucin-5AC OS=Homo sapiens GN=MUC5AC PE=1 SV=4 (MUC5A_HUMAN)	1.981462	4.11-06
17	Q9HD89	Resistin OS=Homo sapiens GN=RETN PE=1 SV=1 (RETN_HUMAN)	1.949174	6.99-06
18	B4DLS7	cDNA FLJ53454, highly similar to interferon-induced protein with tetratricopeptide repeats 3 OS=Homo sapiens PE=2 SV=1 (B4DLS7_HUMAN)	1.911231	1.30-05
19	P06702	Protein S100-A9 OS=Homo sapiens GN=S100A9 PE=1 SV=1 (S10A9_HUMAN)	1.882936	2.06-05
20	C9JKF7	Lymphocyte-specific protein 1 (fragment) OS=Homo sapiens GN=LSP1 PE=1 SV=1 (C9JKF7_HUMAN)	1.878033	2.23-05
21	P52566	Rho GDP-dissociation inhibitor 2 OS=Homo sapiens GN=ARHGDIB PE=1 SV=3 (GDIR2_HUMAN)	1.843884	3.86-05
22	P16402	Histone H1.3 OS=Homo sapiens GN=HIST1H1D PE=1 SV=2 (H13_HUMAN)	1.834376	4.49-05
23	Q7Z351	Putative uncharacterized protein DKFZp686N02209 OS=Homo sapiens GN=DKFZp686N02209 PE=2 SV=1 (Q7Z351_HUMAN)	1.82681	5.07-05
24	D3DP16	Fibrinogen gamma chain, isoform CRA_a OS=Homo sapiens GN=FGG PE=4 SV=1 (D3DP16_HUMAN)	1.818705	5.77-05
25	P40261	Nicotinamide N-methyltransferase OS=Homo sapiens GN=NNMT PE=1 SV=1 (NNMT_HUMAN)	1.792604	8.72-05
26	B7Z747	cDNA FLJ51120, highly similar to matrix metalloproteinase-9 (EC 3.4.24.35) OS=Homo sapiens PE=2 SV=1 (B7Z747_HUMAN)	1.756301	0.000154
27	I1VZV6	Hemoglobin alpha 1 OS=Homo sapiens GN=HBA1 PE=3 SV=1 (I1VZV6_HUMAN)	1.755144	0.000157
28	P02792	Ferritin light chain OS=Homo sapiens GN=FTL PE=1 SV=2 (FRIL_HUMAN)	1.75021	0.000169
29	F5H5I5	ATP-binding cassette sub-family B member 9 (fragment) OS=Homo sapiens GN=ABCB9 PE=4 SV=1 (F5H5I5_HUMAN)	1.746098	0.000181
30	Q6P4A8	Phospholipase B-like 1 OS=Homo sapiens GN=PLBD1 PE=1 SV=2 (PLBL1_HUMAN)	1.732104	0.000224
31	H0YJG9	Dehydrogenase/reductase SDR family member 2, mitochondrial (fragment) OS=Homo sapiens GN=DHRS2 PE=1 SV=1 (H0YJG9_HUMAN)	1.727996	0.000239
32	C9JZJ5	Melanoma-associated antigen 4 (fragment) OS=Homo sapiens GN=MAGEA4 PE=1 SV=7 (C9JZJ5_HUMAN)	1.717063	0.000283
33	P20591	Interferon-induced GTP-binding protein Mx1 OS=Homo sapiens GN=MX1 PE=1 SV=4 (MX1_HUMAN)	1.705117	0.00034
34	Q400J6	Arylamine N-acetyltransferase (fragment) OS=Homo sapiens GN=NAT1 PE=2 SV=1 (Q400J6_HUMAN)	1.6983	0.000377
35	P80723	Brain acid soluble protein 1 OS=Homo sapiens GN=BASP1 PE=1 SV=2 (BASP1_HUMAN)	1.696699	0.000386
36	P05109	Protein S100-A8 OS=Homo sapiens GN=S100A8 PE=1 SV=1 (S10A8_HUMAN)	1.684961	0.000462
37	B2MUD5	Neutrophil elastase (fragment) OS=Homo sapiens GN=ELA2 PE=4 SV=1 (B2MUD5_HUMAN)	1.681383	0.000487
38	P23381	Tryptophan-tRNA ligase, cytoplasmic OS=Homo sapiens GN=WARS PE=1 SV=2 (SYWC_HUMAN)	1.670288	0.000576
39	Q86YQ1	Hemoglobin alpha-2 (fragment) OS=Homo sapiens GN=HBA2 PE=3 SV=1 (Q86YQ1_HUMAN)	1.669802	0.000581
40	A0A0G2JMH6	HLA class II histocompatibility antigen, DR alpha chain OS=Homo sapiens GN=HLA-DRA PE=1 SV=1 (A0A0G2JMH6_HUMAN)	1.663235	0.000641
41	B4DVG3	cDNA FLJ53104, moderately similar to Homo sapiens N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) (NPL), mRNA OS=Homo sapiens PE=2 SV=1 (B4DVG3_HUMAN)	1.662357	0.000649
42	A0A140VJJ6	Testicular tissue protein Li 70 OS=Homo sapiens PE=2 SV=1 (A0A140VJJ6_HUMAN)	1.653489	0.000742
43	B4E0J9	cDNA FLJ57348, highly similar to Homo sapiens hexokinase domain containing 1 (HKDC1), mRNA OS=Homo sapiens PE=2 SV=1 (B4E0J9_HUMAN)	1.653261	0.000744
44	U6FVB0	Tyrosine-protein kinase receptor OS=Homo sapiens GN=CD74-Ntrk1 fusion gene PE=2 SV=1 (U6FVB0_HUMAN)	1.616527	0.001283
45	A2MYE1	A30 (fragment) OS=Homo sapiens PE=4 SV=1 (A2MYE1_HUMAN)	1.599301	0.001651
46	B4DVC2	cDNA FLJ51332, highly similar to HLA class II histocompatibility antigen, DMbeta chain OS=Homo sapiens PE=2 SV=1 (B4DVC2_HUMAN)	1.592926	0.001811
47	Q8IZI0	Hemoglobin beta chain variant Hb-I_Toulouse (fragment) OS=Homo sapiens GN=HBB PE=3 SV=1 (Q8IZI0_HUMAN)	1.592452	0.001823
48	Q6P1N7	TAPBP protein OS=Homo sapiens GN=TAPBP PE=1 SV=1 (Q6P1N7_HUMAN)	1.584238	0.002054
49	B4DNT5	cDNA FLJ60316, highly similar to Apolipoprotein-L1 OS=Homo sapiens PE=2 SV=1 (B4DNT5_HUMAN)	1.577475	0.002264
50	O15451	Proline and glutamic acid-rich nuclear protein isoform (fragment) OS=Homo sapiens PE=2 SV=2 (O15451_HUMAN)	1.576906	0.002282