PDE4 and Epac1 Synergistically Promote Rectal Carcinoma via the cAMP Pathway

Table 1

PDE4 and Epac1 protein levels in rectal cancer tissues.

Protein	Features	Rectal cancer	Paracarcinoma tissues	^2
Epac1	Positive	24	1	11.260	0.01
	Negative	20	15
PDE4	Positive	26	2	10.233	0.01
	Negative	18	14

Note: in rectal cancer and paracarcinoma tissues, PDE4 and Epac1 levels showed a statistically significant difference.