| MMP | Category | Role in the EMT of HCC | Cross-activated by MMP | References |
| MMP-1 | Collagenase | Invasion and metastasis | MMP-3, MMP-7, and MMP-10 | [21, 25, 43, 44] | MMP-2 | Gelatinase | Invasion and metastasis | MMP-1, MMP-7, MMP-12, MMP-13, MMP-14, MMP-15, MMP-16, MMP-17, MMP-24, and MMP-25 | [22–26, 44–46] | MMP-3 | Stromelysin | Invasion and metastasis | MMP-12 | [47–60, 74] | MMP-7 | Matrilysin | Invasion and metastasis | MMP-3, MMP-10 | [21, 50, 51] | MMP-8 | Collagenase | Angiogenesis and migration | MMP-3, MMP-10 | [21, 52–54] | MMP-9 | Gelatinase | Angiogenesis, invasion, and metastasis | MMP-2, MMP-3, MMP-7, MMP-10, and MMP-13 | [21, 24, 55–58, 74] | MMP-10 | Stromelysin | Angiogenesis, invasion, and metastasis | N/A | [59–62] | MMP-11 | Stromelysin | Invasion and metastasis | N/A | [63, 64] | MMP-13 | Collagenase | Invasion and metastasis | MMP-2, MMP-3, MMP-7, MMP-10, MMP-14, and MMP-15 | [22, 25, 26, 65, 66] | MMP-14 | Membrane-type | Invasion and metastasis | MMP-14 | [22, 67, 68] | MMP-16 | Membrane-type | Invasion and metastasis | N/A | [40, 69] | MMP-26 | Matrilysin | Invasion and metastasis | MMP-26 | [25, 70, 71] | MMP-28 | Other | Invasion and metastasis | N/A | [72, 73] |
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