Diagnostic Value Investigation and Bioinformatics Analysis of miR-31 in Patients with Lymph Node Metastasis of Colorectal Cancer

Figure 6

Validation of the expression of miR-31 and hub genes in CRC and controls tissues. (a) Expression of miR-31 and hub gene were detected in 615 CRC tissues and 11 control tissues. miR-31 was significantly upregulated in CRC tissues compared to control tissues. Expression of the hub genes was detected in 638 CRC tissues and 51 control tissues. Six hub genes—PPP3CA, DICER1, CBL, GNA13, SSH1, and TNS1—were significantly downregulated in CRC tissues compared to control tissues. No significant difference of ELAVL1 expression was observed between CRC tissues and control tissues. (b) Correlation analysis showed that TNS1 expression level was negatively correlated with miR-31 expression level in CRC and control tissues.

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