Cytochrome P450 Epoxygenase-Dependent Activation of TRPV4 Channel Participates in Enhanced Serotonin-Induced Pulmonary Vasoconstriction in Chronic Hypoxic Pulmonary Hypertension

Figure 1

The effect of HC-067047 and MS-PPOH in normoxic WT mice. (a) Cumulative concentration-response curve of 5-HT, in PAs of WT mice with vehicle, MS-PPOH preincubation, and with HC-067047 preincubation, respectively. Data are expressed as a percentage of K⁺-induced contractile responses (60 mM). (b, c) Bar graph showing the contractile response of normoxic PAs of WT mice, WT mice with HC-067047 preincubation and WT mice with MS-PPOH preincubation to serotonin. Mean values of maximal response () and is derived from experiments shown in (a). and were calculated from each individual PA using the 3-parameter logistic equation described in Materials and Methods. .

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