Uncontrolled growth is a fundamental hallmark of cancer biology. This unrestricted proliferation of cancer cells relies on their ability to generate biomass and ultimately on nutrient supply. Of note, many oncogenes and signalling pathways altered in cancer rewire the metabolism of cancer cells and may increase the dependency on specific metabolic pathways to enhance cell cycle progression and tumour growth. In addition, this metabolic reprogramming has also been linked with other features related to tumour progression, such as cell migration.

The epithelial-mesenchymal transition (EMT) is a complex process by which epithelial cells acquire the motile and invasive features of mesenchymal cells. This process is important for the migration of cancer cells, and therefore, crucial for metastasis. Thus, the identification of novel metabolic dependencies that sustain tumour cell growth, cell cycle progression, and cell migration in cancer is highly relevant due to their potential use as therapeutic targets.

The aim of this Special Issue is to invite authors to contribute with novel evidence in which the metabolism and/or signalling pathways are targeted against cancer and/or processes related to cancer. In addition, we also welcome contributions that aim to improve methods of metabolites detection and review articles providing an updated vision of the fields of cancer metabolism, cell signalling, cell cycle, and/or migration.

Potential topics include but are not limited to the following:

• New strategies to target metabolic pathways for cancer treatment
• New strategies to target signalling pathways for cancer treatment
• Novel links between cell signalling and metabolic pathways
• Novel links between metabolic pathways and cell cycle progression
• Role of metabolism in cell migration and invasion
• Role of metabolic reprogramming in epithelial-mesenchymal transition
• Cation channels in cell signalling and metabolism
• Novel methodologies to detect or improve the detection of polar and non-polar metabolites involved in cancer