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Autoimmune Diseases
Volume 2010 (2010), Article ID 176749, 4 pages
http://dx.doi.org/10.4061/2010/176749
Case Report

Drug-Induced Bullous Sweet Syndrome with Multiple Autoimmune Features

1Department of Dermatology, Marshfield Clinic, 1000 N. Oak Avenue, Marshfield, 54449, USA
2Department of Internal Medicine, Marshfield Clinic, 1000 N. Oak Avenue, Marshfield, 54449, USA
3Department of Pathology, Marshfield Clinic, 1000 N. Oak Avenue, Marshfield, 54449, USA
4Department of Rheumatology, Marshfield Clinic, 1000 N. Oak Avenue, Marshfield, 54449, USA

Received 12 March 2010; Revised 25 June 2010; Accepted 1 August 2010

Academic Editor: Thomas Dörner

Copyright © 2010 Jared J. Lund et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Sweet syndrome (SS) (Acute Febrile Neutrophilic Dermatosis) has been reported in association with autoimmune phenomena including relapsing polychondritis, drug-induced lupus, and the development of antineutrophil cytoplasmic antibodies (ANCAs). However, a combination of these autoimmune features has not been reported. Herein, we report a case of drug-induced bullous SS with ocular and mucosal involvement, glomerulonephritis, and multiple autoimmune features including clinical polychondritis with antitype II collagen antibodies, ANCAs, antinuclear (HEp-2), and antihistone antibodies in a patient on hydralazine and carbamazepine.