5-Androstenediol Ameliorates Pleurisy, Septic Shock, and Experimental Autoimmune Encephalomyelitis in Mice
Figure 2
Effect of 5-AED on serum levels of TNF in a murine model of LPS-induced shock. CD-1 mice (males, 4 per group) were treated (s.c. injection) with 5-AED (0.4, 4.0 or 40 mg/kg) 24 hours before and 1 hour after IP challenge with LPS (0.5 mg). 2 hours after the LPS challenge, mice were killed and serum levels of TNF are measured by ELISA. All values in the figures are expressed as mean ± one standard deviation. These studies were repeated three times with similar results. *indicates significant () difference when compared to control values.
