Research Article

5-Androstenediol Ameliorates Pleurisy, Septic Shock, and Experimental Autoimmune Encephalomyelitis in Mice

Table 1

Competition binding IC50 values of dihydrotestosterone (DHT), estradiol (E2), and androstenediol (5-AED) for AR, ER , and ER .

LigandReceptor*

DHT15 nM 4.2 ( )ND**ND
E2ND8 nM 5.4 ( )7 nM 1.6 ( )
5-AED210 nM 44 ( )49 nM 13 ( )10 nM 3.4 ( )

are expressed as IC50 values in nM units, representing the statistical mean ± SEM. The numbers in parenthesis represent the number of independent experiments performed ( value). See text for details of procedures.
: Human androgen receptor.
: Human estrogen receptor .
: Human estrogen receptor .
**ND: Not determined.