Effects of IFN-B on TRAIL and Decoy Receptor Expression in Different Immune Cell Populations from MS Patients with Distinct Disease Subtypes
Figure 3
Relative quantification of TRAIL death (TRAIL-R1, TRAIL-R2) and decoy receptor (TRAIL-R3, TRAIL-R4) mRNAs in B cells. (a) TRAIL-R1, (b) TRAIL-R3 and (d) TRAIL-R4 mRNA levels were not altered by IFN-β treatment or different between the various groups (NS group and MS subtypes). Insufficient amounts of B cell RNA were isolated to permit analysis of TRAIL-R4 levels for PPMS patients. (c) TRAIL-R3 gene expression was increased in SPMS patients irrespective of IFN-β treatment condition (SPMS NO IFN and SPMS IFN groups not different and therefore pooled) relative to the RRMS group. *, Dunn’s post-hoc test.
