The Caspase Pathway as a Possible Therapeutic Target in Experimental Pemphigus

<table>Caspase 3 activity detected in mouse skin. Note the presence of caspase 3 in a blister induced by the injection of pemphigus vulgaris IgG, and the presence of cytokeratin 18 detected using the antibody M30 which recognises a neoepitope of cytokeratin 18 formed after caspase cleavage. Positive immunohistochemistry was exhibited in both cases (arrows). Note the inhibition induced by the synthetic peptide Ac-DEVD-CMK in the bottom row.</table>

Autoimmune Diseases

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Figure 4

Figure 4: The Caspase Pathway as a Possible Therapeutic Target in Experimental Pemphigus 