miRNA genes are transcribed in the form of Pri-miRNA. The DGCR8-Drosha complex processes in the form Pre-miRNA followed by transport into cytoplasm by Exportin-5. In cytoplasm, Pre-miRNA is processed by Dicer into miRNA duplex. Of miRNA duplex, one strand is loaded into RISC complex, which functions for either mRNA degradation or translational repression.
