MicroRNAs and Multiple Sclerosis

Table 3

Significantly altered miRNAs upon stimulation LPS in N9 microglial cells.

MicroRNA	Microarray		qPCR		Targets
	Fold change	𝑃	Fold change	𝑃
mmu-miR-105	0.35	.02	ns		not determined
mmu-miR-125b-3p	2.81	ns	0.16	.047	IL-1β, IL-13, TNF-α
mmu-miR-191	3.12	ns	0.21	.032	CCL9, CRP, IL-6, TLR-3
mmu-miR-193*	0.26	.03	0.28	.047	CCL6, IL-10, IL-12Rγ
mmu-miR-208a	3.01	ns	0.12	.015	CD8, IL-18BP, IL-24
mmu-miR-224	3.73	ns	0.09	.033	CD53, CXCL-14, IL-11
mmu-miR-297c*	0.31	ns	0.12	.033	not determined
mmu-miR-324-3p	0.33	ns	0.18	.049	not determined
mmu-miR-376c	2.99	.01	ns		not determined
mmu-miR-421	0.35	ns	0.03	.033	not determined
mmu-miR-431*	4.62	ns	0.22	.034	CD5, CD81, DICER, IRAK1, TRAP 1
mmu-miR-669g	3.48	ns	0.15	.015	not determined
mmu-miR-1190	0.28	.01	0.12	.016	not determined
mmu-miR-1894-5p	0.34	ns	0.08	.017	not determined

CCL9: chemokine (C-C) motif ligand 9; CXCL-14: chemokine (C-X-C) motif ligand 14; CRP: c reactive protein; IL-1β: interleukin 1-β; IL-6: interleukin-6; IL-10: interleukine-10; IL-11: interleukin-11; IL-12Rγ: interleukin 12 receptor γ; IL-13: interleukin-13; IL-18BP: interleukin-18 binding protein; IL-24: interleukin-24; IRAK1: interleukin-1 receptor associated kinase-1; TLR-3: Toll-like receptor-3; TRAP 1: TNF receptor associated protein 1; TNF-α: tumor necrosis factor-α.