A Systematic Review of Serum Biomarkers Anti-Cyclic Citrullinated Peptide and Rheumatoid Factor as Tests for Rheumatoid Arthritis

Table 2

Anti-CCP tests.

Manufacturer/test type	Test*	Cut point (U/mL)	Sensitivity (%)	Specificity (%)	References
Abbott Laboratories	Anti-CCP	5	69.4	97.6	[23]
	AxSYM	5	80.6	84.3	[24]
	Anti-CCP2
Axis-Shield Diagnostics	Anti-CCP	7.2	52.8	100	[25]
	Anti-CCP2	4.5	82.4	82.8	[26]
		4.6	83.3	93	[27]
		5	53.7–67.5	90.4–99.3	[28–31]
		5.6	88	81	[32]
		25	71	65	[10]
Eurodiagnostica	Anti-CCP	20.7	52.8	100	[25]
		53	47	94	[33]
		65	43.8	98.4	[34]
	Anti-CCP2	5	66.7	97	[29]
		25	66.7–76.5	92.2–97.3	[29, 35–37]
		42	73.7	98.6	[36]
Euroimmun	Anti-CCP	5	39.2–65	95.2–99	[38–41]
		14.8	81.6	87.5	[42]
		25	56	96	[43]
	Anti-CCP2	5	66.7–72.5	96.4–97.7	[29, 35]
		5.25	78.7	95.6	[44]
Fuchun-Zhongnan Biotech	Anti-CCP2	25	61.8	96.3	[45]
Genesis	Anti-CCP2	6.25	69.6	93.9	[35]
Immunoscan	Anti-CCP2	25	54–64.4	96–97.1	[46, 47]
In-house ELISA test	Anti-CCP1	92	42	97	[47]
INOVA Diagnostics	Anti-CCP	6.4	58.5	100	[25]
	Anti-CCP2	20	60.2–78.6	70.3–98.8	[22, 24, 29, 35, 48–52]
		25	82	96	[53]
		30	70	91.5	[54]
	Anti-CCP3	20	61.3–82.9	93–97.6	[24, 29, 49, 51]
MBL Co.	Anti-CCP	3.8	72.8	92	[55]
Phadia GmbH	Anti-CCP2	7	77.5	95.9	[35]
		10	70.1	98.7	[56]
Pharmacia Diagnostica	Anti-CCP2	7	80.3	97	[22]
Roche Diagnostics	Anti-CCP2	9	69	93	[57]
		13.6	92.2	86.2	[58]
		17	90.6	86.8	[58]

^∗The generation of anti-CCP test indicated is as reported in the methods section of the articles referenced.