A Systematic Review of Serum Biomarkers Anti-Cyclic Citrullinated Peptide and Rheumatoid Factor as Tests for Rheumatoid Arthritis

Table 3

2010 ACR/EULAR scoring criteria for RA. The following table provides the scoring criteria for different domains of evaluation. For each cell in the table for which the patient satisfies the condition, the cell is scored by the number of points at the top of the column in which it is found. The patient’s score is the sum of the scores for the individual cells. Patients with a total score of 6 or more points are diagnosed as having RA.

Number of points	0	1	2	3	5
Joint involvement	1 medium-large joint	2–10 medium-large joints	1–3 small joints	4–10 small joints	>10 small joints
Serology	Negative for both RF and anti-CCP	Positive for either RF or anti-CCP at low titer (between 1x and 3x upper limit of normal)	Positive for either RF or anti-CCP at high titer (>3x upper limit of normal)
Duration of synovitis	<6 weeks	≥6 weeks
Acute phase reactants	normal CRP and ESR	abnormal CRP or ESR

Source: [97].