Aberrant Activation of Heat Shock Protein 60/65 Reactive T Cells in Patients with Behcet’s Disease

Table 2

Conserved peptide sequences of mycobacterial HSP65 and human HSP60 [20].

Mycobacterial HSP65

(111-125)

N

P

L

G

L

K

R

G

I

E

K

A

V

E

K

Human HSP60

(136-150)

N

P

V

E

I

R

R

G

V

M

L

A

V

D

A

Mycobacterial HSP65

(154-172)

Q

S

I

G

D

L

I

A

F

A

M

D

K

V

G

N

E

G

V

Human HSP60

(179-197)

K

E

I

G

N

I

I

S

D

A

M

K

K

V

G

R

K

G

V

Mycobacterial HSP65

(219-233)

L

L

V

S

S

K

V

S

T

V

K

D

L

L

P

Human HSP60

(244-258)

L

L

S

E

K

K

I

S

S

I

Q

S

I

V

P

Mycobacterial HSP65

(311-326)

D

L

S

L

L

G

K

A

R

K

V

V

V

T

K

D

Human HSP60

(336-351)

Q

P

H

D

L

G

K

V

G

E

V

I

V

T

K

D

The four peptide sequences were well conserved between human HSP60 and mycobacterial HSP65. Peptide 336–351 derived from human HSP60 effectively stimulated the pathogenic T cells in patients with BD [10, 20–22].