Autoimmune Hepatitis as a Unique Form of an Autoimmune Liver Disease: Immunological Aspects and Clinical Overview

Table 1

Revised scoring system for the diagnosis of autoimmune hepatitis.

Parameters/features	Score	Notes*
Female sex	+2
ALP : AST (or ALT) ratio:
<1.5	+2	1
1.5–3.0	0
>3.0	−2
Serum globulins or IgG above normal
>2.0	+3
1.5–2.0	+2
1.0–1.5	+1
<1.0	0
ANA, SMA, or LKM-1
>1 : 80	+3	2
1 : 80	+2
1 : 40	+1
<1 : 40	0
AMA positive	−4
Hepatitis viral markers:
Positive	−3	3
Negative	+3
Drug history:
Positive	−4	4
Negative	+1
Average alcohol intake
<25 g/day	+2
>60 g/day	−2
Liver histology:
Interface hepatitis	+3
Predominantly lymphoplasmacytic infiltrate	+1
Rosetting of liver cells	+1
None of the above	−5
Biliary changes	−3	5
Other changes	−3	6
Other autoimmune disease(s)	+2	7
Optional additional parameters:		8
Seropositivity for other defined autoantibodies	+2	9
HLA DR3 or DR4	+1	10
Response to therapy:
Complete	+2	11
Relapse	+3
Interpretation of aggregate scores:
Pretreatment:
Definite AIH	>15
Probable AIH	10–15
Posttreatment:
Definite AIH	>17	12
Probable AIH	12–17

∗[36].