Evaluation of ENA-6 Profile by ELISA Immunoassay in Patients with Systemic Lupus Erythematodes

Table 2

Optimal cut-off, area under the curve with 95% confidence interval (AUC, 95% CI), sensitivity, specificity, positive and negative predictive value of ENA6, SM, and CIC in differencing between SLE patients and healthy control.

SLE patients versus healthy control
Marker	Optimal; cut-off	AUC (95% CI)	Sensitivity (%)	Specificity (%)	Positive predictive value (%)	Negative predictive value (%)
ENA6 Sm	≥9,56 EU	0,809 (0,690–0,928)	70%	100%	100%	76%
CIC	≥54,24 EU	0,931 (0,854–1,00)	76%	100%	100%	81%

SLE: systemic lupus erythematosus; AUC: area under the curve; CI: confidence interval; ENA6 Sm: extractable nuclear antigens 6 Sm; CIC: circulating immune complexes; EU: elisa units.