A Comparison of Epitope Repertoires Associated with Myasthenia Gravis in Humans and Nonhuman Hosts

Table 5

HLA association.

HLA serotype	Epitope sequence from hAChR
A2, A29, B7, DR2, DR7	STHVMPNWVRKVFIDTIP
	IPNIMFFSTMKRPSREKQ
	AIVKFTKVLLQYTGHITWTP
	QIVTTNVRLKQQWVDYNLKW
	IIGTLAVFAGRLIELNQQG
DQ9, DQ6, DR9, DR13	PLFSHLQNEQWVD
DQ6, DQ7, DQ2, DQ8	DLVLYNNADGDFAIVK
DR2, DR5	FLMAHYNRVPALPFPGDPRP
	LWVLRVPSTMVWRPDIVLEN
	IVVNAVVVLNVSLRSP
	VRKVFLRLLPQLLRMHVRPL
DR2, DR5, DR3	NRVPALPFPGDPRPYLPSPD
DR3	PPAIFRSACSISVTYFPFDW
	FPFDWQNCSLIFQSQTYSTN
	GQTIEWIFIDPEAFTENGEW
DQ2, DQ7, DQ3t12	IHIPSEKIWRPDLVLY
DR3, DR11	IWRPDVVLYNNADGDFAIVKFTKVLLDYTGHITWTPPAIFKSYCEIIVTHFPFDEQNC
DQ8, DQ2, DQ6, DQ7, DQ3t12, DQ3.33	PDTPYLDITYHFVMQRL
DQ8	AIFKSYCEIIVTHFPFD
DQ8, DQ5, DQ7, DQ2, DQ3t12	EVNQIVTTNVRLKQQW
DQ8, DQ5, DQ6, DQ7, DQ3.33, DQ3t12	EDHRQVVEVTVGLQLI
DQ8, DQ6, DQ7, DQ3.33, DQ3t12	WNPDDYGGVKKIHIPS
DQ8, DQ6, DQ7, DQ2, DQ3t12	RGWKHSVTYSCCPDTPY
DQ8, DQ7, DQ3t12	HFPFDEQNCSMKLGTWT
DQ8, DQ6, DQ3.33	LKQQWVDYNLKWNPDD
DQ2, DQ5, DQ6	FMESGEWVIKESRGWKH
DQ2, DQ5, DQ7, DQ3t12	GLQLIQLINVDEVNQI
DQ2, DQ6	SEHETRLVAKLFKDYS
DQ2, DQ6, DQ5, DQ7, DQ3.33	LGTWTYDGSVVAINPES
DQ2, DQ6, DQ7, DQ3.33	QYTGHITWTPPAIFKS
DQ2, DQ7, DQ6, DQ5, DQ8, DQ3t12, DQ3.33	FKDYSSVVRPVEDHRQ
DQ2, DQ8, DQ5	INPESDQPDLSNFMESG

Data were retrieved by querying for all human data against all AChRs. T- and B-cell Assay data were downloaded separately into Excel format and used to filter on the column “h_mhc_types_present.” The Allele Finder on the homepage was used to decipher serotype from complex alleles. Prolif: T-cell proliferation assay; exac: disease exacerbation assays; IFNg or IL-2: cytokine release assays.