Autoimmune Diseases / 2012 / Article / Tab 4 / Review Article
Heat Shock Proteins: Pathogenic Role in Atherosclerosis and Potential Therapeutic Implications Table 4 Summary of studies on potential heat shock protein-related treatments for various diseases.
Study Disease Subjects Study summary and major findings Maron et al. [74 ] Atherosclerosis Mice Nasal vaccination with HSP65 resulted in a significant decrease in the size of atherosclerotic plaques, a reduced number of T cells, and an increased IL-10 expression Harats et al. [75 ] Atherosclerosis Mice Oral tolerance induced with HSP65 led to a reduction in atherosclerosis Jun et al. [77 ] Atherosclerosis Rabbits Vaccine targeting HSP65 and cholesterol ester transfer protein reduced low-density lipoprotein levels and atherosclerotic burden Ishii et al. [80 ] Multiple myeloma Human The addition of an HSP90 inhibitor enhanced the antitumor activity of a proteasome inhibitor both in vitro and in vivo Kaiser et al. [81 ] Acute leukemia Human HSP70 inhibitor displayed antileukemic effects both alone and in combination with other antineoplastic agents