The Autoimmune Tautology: An In Silico Approach

Table 3

Genes with a contribution higher than 0.1% to the found clusters of the studied autoimmune diseases.

Cluster 1. SLE-SS		Cluster 2. T1D-AITD		Cluster 4. RA-MS
Gene	%	Gene	%	Gene	%
TRIM21	27.91	TPO	32.4	TNF	39.5
TNFSF13B	27.46	CTLA4	28.6	HLA-DRB1	20.7
TROVE2	19.8	TNFRSF25	6.7	IL10	5.2
SSB	6.6	HLA-DRB1	6.7	IL6	2.2
FAS	2.7	PTPN22	6.4	CCL2	0.6
DLAT	2.6	GAD1	4.6	CD4	0.6
IRF5	1.0	GAD2	3.6	MMP9	0.6
IL10	0.9	AIRE	1.7	IL1B	0.5
FASLG	0.8	PTPRN	1.5	IL4	0.5
TNFRSF25	0.6	HLA-DQB1	0.5	TNFSF13B	0.5
CR1	0.5	IDDM2	0.5	IL23A	0.4
CALR	0.5	SUMO4	0.5	CCR2	0.4
SPTAN1	0.4	ICA1	0.4	IL1RN	0.4
RNPC3	0.4	FOXP3	0.3	CCL5	0.3
CR2	0.2	FCRL3	0.2	ICAM1	0.3
SNRNP70	0.2	CD4	0.2	CXCR3	0.3
SERPIND1	0.2	FASLG	0.2	HLA-DQB1	0.3
C1QA	0.2	CXCL10	0.2	VCAM1	0.2
IL18	0.2	CD8A	0.2	CTLA4	0.2
IL6	0.2	IL1B	0.2	PADI4	0.2
		TSHR	0.2	IFNB1	0.2
				CRP	0.2
				CCR5	0.2
				IL12B	0.2

SLE: systemic lupus erithematosus, SS: Sjögren’s syndrome, T1D: type 1 diabetes, AITD: autoimmune thyroid disease, RA: rheumatoid arthritis, MS: multiple sclerosis, %: percentage of contribution to the cluster.