Multiple Autoantibodies Display Association with Lymphopenia, Proteinuria, and Cellular Casts in a Large, Ethnically Diverse SLE Patient Cohort

Table 3

Conditional multivariate adjusted logistic regression models within European-American, African-American, and Hispanic populations using ACR SLE criteria or subcriteria as outcome and individual autoantibodies and sex as covariates.

Criteria/subcriteria	Covariates	European American		African American		Hispanic
		Odds ratio (95% CI)	𝑃 value	Odds ratio (95% CI)	𝑃 value	Odds ratio (95% CI)	𝑃 value
	60 kD Ro	3.31 (1.57, 6.99)	0.0017
	RNP 68	4.37 (1.10, 3.74)	0.0361
Hematological disorder	Sm/RNP			3.03 (1.21, 7.61)	0.0184
	La			3.59 (1.07, 12.06)	0.0384
	RNP A					11.93 (1.53, 93.37)	0.0182
Leukopenia	Ribo P	3.77 (1.22, 11.60)	0.0207	3.16 (1.25, 8.00)	0.0154
	RNP 68	5.23 (1.40, 19.54)	0.0139
Lymphopenia	52 kD Ro	2.95 (1.39, 6.29)	0.0050	2.90 (1.33, 6.31)	0.0072
	dsDNA					0.18 (0.05, 0.69)	0.0124
	Chromatin					6.05 (1.70, 21.54)	0.0055
Hemolytic anemia	Chromatin					0.10 (0.01, 0.95)	0.0446
	Chromatin	2.56 (1.32, 4.95)	0.0054
	La	0.33 (0.13, 0.88)	0.0273
Renal disease	Sm	0.28 (0.10, 0.76)	0.0127
	dsDNA			2.38 (1.11, 5.08)	0.0255
	Sex			4.40 (1.17, 15.56)	0.0283
	Chromatin	2.34 (1.23, 4.44)	0.0092
Proteinuria	La	0.29 (0.11, 0.74)	0.0096
	Sm	0.36 (0.14, 0.94)	0.0366
	Sex			4.04 (1.11, 14.74)	0.0346
Cellular cast	dsDNA			3.26 (1.25, 8.50)	0.0158
	Sm/RNP			2.91 (1.24, 6.81)	0.0138
Seizures	Sm/RNP	5.33 (1.15, 24.80)	0.0329
	RNP A	0.013 (0.02, 0.67)	0.0156
Oral ulcer	Sm/RNP			1.97 (1.04, 3.71)	0.0368
Malar rash	La	0.42 (0.20, 0.89)	0.0233
	Sex	3.23 (1.38, 7.55)	0.0068
	52 kD Ro			0.07 (0.01, 0.53)	0.0103
Photosensitivity	La			11.87 (1.37, 103.19)	0.0250
	Sex	2.30 (1.00, 5.29)	0.0495