CD91-Dependent Modulation of Immune Responses by Heat Shock Proteins: A Role in Autoimmunity

Table 1

A summary of reported antigen cross-presenting systems described for HSP-chaperoned peptides and the corresponding receptor.

HSP	Antigen presenting cell	Uptake mechanism	Reference and year	Notes
rhsp70 (bovine), rhsp70 (human)	Bovine cultured monocytes, B-LCL lines L721.45 and L721.174, and human monocytes	Macropinocytosis	[38] 2010, [39] 2007	CD4 stimulation
rgp96, gp96 and hsp70, rhsp70 (human), hsp70 (human), rhsp70	BMDC, macrophage cell line (p388d1) and DC line (D2SC1), RAW264.7 and RAW309Cr.1, human monocytes, elicited PEC	Receptor (unidentified) mediated endocytosis	[40] 2011, [26] 1999, [41] 2008, [42] 2002, [31] 2000	Differences in lipid raft involvement with N or C terminus of HSP70, also MHC II presentation
gp96, hsp90, hsp70, CRT, (E. coli and Mtb) hsp70, gp96 (frog), rhsp70 (human)	B-LCL, human DC, RAW264.7 and peritoneal macrophages, BMDCs, BM-macrophages, CD11c+ cells, frog macrophage-like cells, human PBMC	CD91	[35] 2004, [23] 2000, [24] 2001, [43] 2004, [44] 2004, [45] 2008, [46] 2011	MHC I and II presentation
rhsp70 (human) and rhsp60 (human)	Human monocytes, epidermal LC	CD91	[28] 2002	Internalization with MHC I and II
gp96	Splenic APC, B220+, CD11c+, CD11b+, BMDC	CD91 and partial Lox-1	[37] 2010	MHC II presentation
rhsp70 (human)	Monocytes, MDDC	CD91 and partial CD36/scavenger receptor	[47] 2010	MHC II presentation and CD4 memory
rhsp70 (M. avium paratuberculosis)	Bovine macrophage cell line BoMac, bovine DC, macrophages, and monocytes	CD91 and other	[48] 2005
gp96 (porcine), rgp96 (canine, NTD)	Elicited peritoneal macrophages, MEF-1, PEA-13, DC2.4		[49] 2002, [50] 2010	MHC I and II presentation
hsp90 (human, purified), rhsp72 (human)	RMA-S/A*2402, BMDC	Receptor dependent	[30] 2007
rhsp90 (human)	BMDC, CHO, HeLa and RAW264.7	SREC-1 and Lox-1	[51] 2010
rCRT	DC2.4, elicited peritoneal macrophage, MEF-1, PEA-13	SREC-1	[52] 2005
gp96 (porcine) and rCRT	CHO, elicited peritoneal macrophages, BMDC	SREC-1	[53] 2004
rhsp70	Human myeloid DC, monocytes, macrophages, CD19+ cells	Lox-1	[54] 2002
gp96 (porcine) and rCRT	Elicited peritoneal macrophages, RAW264.7, HEK	SRA	[55] 2003
rgp96 and rCRT	Fibroblasts, BMDC and BM macrophages	SRA and other	[56] 2008
rgrp170 and rhsp110	RAW264.7, DC1.2, CHO, BMDC	SREC-1 and SRA	[57] 2007
gp96	D2SC/1, D1, BMDC, splenic DC, macrophages, and B cells	Receptor dependent but not MHC class II or DEC205	[27] 2000	Internalization with MHC I and II
gp96 (porcine)	Elicited peritoneal macrophages, RAW264.7, CHO, COS7, BRL	Unidentified receptor mediated and macropinocytosis	[58] 1999
gp96 (porcine)	Elicited peritoneal macrophages, RAW264.7, BMDC	Unidentified receptor mediated and macropinocytosis	[29] 2002