Recombinant T-Cell Receptor Ligand (RTL) for Treatment of Multiple Sclerosis: A Double-Blind, Placebo-Controlled, Phase 1, Dose-Escalation Study
Figure 5
Pharmacokinetic profile of RTL1000. The mean concentration of RTL1000 was assessed in plasma collected from study subjects at the indicated times prior to and after IV infusion of 6 mg (Cohort 2) or 100 mg (Cohort 6) RTL1000. Based on these and other assessments (not shown), the half-life of RTL1000 was determined to be min, with increasing exposure (Cmax and AUClast) observed with increasing dose. Clearance values ranging from 3250 to 44800 mL/min were much greater than hepatic blood flow and indicate that RTL1000 was rapidly eliminated via a nonhepatic mechanism. The high nonphysiological volumes of distribution ranging from 30.8 to 202 liters indicate that RTL1000 is tightly bound to sites not present in plasma.
