Immunosenescence, Aging, and Systemic Lupus Erythematous

<table>Age-related changes in the generation and function of B cells. There is a reduced output of B cells in the bone marrow, which induces accumulations in the periphery of antigen-experienced subsets with poor immune response and low diversity.  HSC: hematopoietic stem cell; BCR: B-cell receptor; BM: bone marrow (adapted from [<a href="/journals/ad/2013/267078/#B49">33</a>]).</table>

Autoimmune Diseases

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Figure 5

Figure 5: Immunosenescence, Aging, and Systemic Lupus Erythematous 