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Autoimmune Diseases
Volume 2013 (2013), Article ID 651497, 7 pages
http://dx.doi.org/10.1155/2013/651497
Review Article

NETosis

Rheumatology Section, Universidad de Antioquia, Medellin, Colombia

Received 25 September 2012; Accepted 23 December 2012

Academic Editor: M. Cutolo

Copyright © 2013 Miguel Antonio Mesa and Gloria Vasquez. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Neutrophils are the first line of defense of the immune system against infection. Among their weaponry, they have the ability to mix and extrude their DNA and bactericidal molecules creating NET-like structures in a unique type of cell death called NETosis. This process is important in order to control extracellular infections limiting collateral damage. Its aberrant function has been implicated in several human diseases including sepsis and autoimmune disease. The purpose of the present paper is to give a general introduction to this concept.