Genome-Wide Association Study of Antiphospholipid Antibodies
Table 2
Genetic loci associated with the occurrence of ACL with *.
CHR
Gene
Lead SNP
BP
Total SNPs
MAF
OR
Negative
Positive
5
PELO
rs6889746
51742663
3
0.3534
0.5
1.776
1
SGIP1
rs6681460
66895645
28
0.3755
0.5168
1.827
6
LCA5
rs12204683
80212978
4
0.2378
0.3701
1.877
4
MIR4275
rs17642174
28160435
6
0.1355
0.2346
2.021
4
C4orf37
rs13134014
99323902
21
0.1517
0.2542
1.928
7
BZW2
rs6961256
16697717
3
0.01261
0.05587
5.214
2
FAM49A
rs6753768
16483918
11
0.2836
0.1648
0.5016
4
MAD2L1
rs10518344
3
0.05136
0.1178
2.696
11
KIRREL3
rs1793667
1
0.2789
0.3966
1.781
14
YLPM1
rs2241275
74321193
7
0.435
0.5587
1.754
14
PROX2
rs4899536
74386367
2
0.4331
0.5559
1.752
2
ATL2
rs6749177
38531205
11
0.4958
0.3659
0.576
17
PRPSAP1
rs11077813
71848140
1
0.2704
0.1564
0.5072
9
TTLL11
rs10985483
4
0.3703
0.25
0.5571
8
ZBTB10
rs406629
81620942
6
0.3795
0.2599
0.5501
21
LINC00317
rs2827107
22175926
3
0.2128
0.3156
1.847
7
NUPL2
rs10232205
23197079
1
0.09244
0.02793
0.2465
1
DUSP10
rs11118750
4
0.2174
0.3287
1.753
15
MCTP2
rs1863095
92917093
1
0.3224
0.4511
1.665
17
SHPK
rs222790
3478239
1
0.2051
0.3097
1.793
6
KHDRBS2
rs2752976
63486388
11
0.431
0.5447
1.688
5
GLRA1
rs154111
14
0.4569
0.3399
0.5875
9
MIR548AA1
rs4836873
4
0.3651
0.2514
0.5746
1
LOC100505918
rs16860501
1
0.09119
0.1648
2.116
19
OR7A10
rs4808564
14825095
1
0.05126
0.1117
2.449
9
C9orf46
rs4742085
5340548
2
0.3501
0.4678
1.696
9
PTPRD
rs2484741
10477877
7
0.2977
0.1983
0.5439
16
PDXDC1
rs3198697
15037441
1
0.3658
0.4859
1.646
CHR: chromosome; Gene: a plausible biological candidate gene in the locus or the nearest annotated gene to the lead SNP; Lead SNP: most significant SNP in the gene region; BP: base-pair position of the lead SNP; Total SNPs: total number of SNPs with in the gene region; MAF: minor allele frequencies in antibody-negative and antibody-positive groups; OR: odds ratio; : -values for the test.
