Genome-Wide Association Study of Antiphospholipid Antibodies
Table 3
Genetic loci associated with the occurrence of lupus anticoagulant (LAC) with *.
CHR
Gene
Lead SNP
BP
Total SNPs
MAF
OR
Negative
Positive
22
MICAL3
rs1978968
16828113
8
0.2144
0.3553
2.235
2
FAM176A
rs17011455
75643997
1
0.01661
0.06967
5.211
20
DSTN
rs17791782
17514069
2
0.07867
0.1721
2.628
6
SUPT3H
rs9472374
44904278
1
0.01957
0.07083
4.77
3
LRIG1
rs4549225
66850149
10
0.3735
0.5246
1.867
1
SMYD3
rs7527610
2
0.005236
0.04098
10.19
14
PELI2
rs754314
55822350
8
0.04833
0.1167
3.111
20
BFSP1
rs16999416
17489830
1
0.08494
0.1777
2.412
16
NDRG4
rs11862356
57067820
1
0.05846
0.1393
2.745
17
CDRT15P1
rs7208809
13678048
2
0.06806
0.1516
2.573
22
FAM19A5
rs9615320
47219591
2
0.1065
0.2008
2.333
6
SNRNP48
rs17398435
7549105
1
0.06392
0.1446
2.589
14
OTX2
rs12897597
56314078
1
0.1531
0.2667
2.097
17
RBFOX3
rs16972153
74719776
1
0.04974
0.1148
2.925
16
MAF
rs9935211
78440577
5
0.05467
0.1311
2.692
5
YTHDC2
rs6865651
2
0.1848
0.3058
2.005
10
LDB3
rs4934256
88490345
2
0.05507
0.123
2.783
9
KLF4
rs1888617
1
0.2657
0.4009
1.935
10
TACC2
rs12773310
6
0.3536
0.219
0.4945
6
LY86
rs9328374
6536628
1
0.1875
0.307
1.989
9
ZCCHC7
rs7031314
37366122
3
0.2204
0.3375
1.924
3
SETD5
rs17050346
9456593
5
0.01926
0.06967
4.047
4
COL25A1
rs13104799
6
0.2245
0.1107
0.4106
7
C7orf58
rs12537243
1
0.09178
0.1736
2.289
4
RBM46
rs7687314
6
0.4474
0.5902
1.808
9
LOC100506710
rs10973184
37056617
1
0.09895
0.1885
2.252
3
EPHA6
rs4318565
97564200
1
0.03369
0.08607
3.32
11
LOC283143
rs1393275
3
0.05026
0.1261
2.595
18
MAPRE2
rs573269
30863716
1
0.3129
0.4385
1.816
13
FARP1
rs285031
97584032
1
0.1489
0.2438
2.092
10
ANXA2P3
rs10822492
66751936
15
0.3439
0.219
0.5075
6
TBCC
rs11759402
42831787
4
0.1658
0.2686
1.945
4
LNX1
rs6831173
54085908
4
0.1337
0.2377
1.962
4
SLC7A11
rs10440463
3
0.2073
0.3238
1.88
1
HHAT
rs1028383
1
0.2248
0.3475
1.882
11
WT1
rs2207549
32325033
2
0.4202
0.2833
0.5274
4
FAM198B
rs17036867
12
0.02747
0.08621
3.54
CHR: chromosome; Gene: a plausible biological candidate gene in the locus or the nearest annotated gene to the lead SNP; Lead SNP: most significant SNP in the gene region; BP: base-pair position of the lead SNP; Total SNPs: total number of SNPs with in the gene region; MAF: minor allele frequencies in antibody-negative and antibody-positive groups; OR: odds ratio; : -values for the test.